Assay Detail
Toxicity
CHEMBL5043389
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG expressed in CHO cells at holding potential of -80 mV by whole cell patch clamp assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, biological, and structural explorations of a series of μ-opioid receptor (MOR) agonists with high G protein signaling bias.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.95 | 5.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2443262 | OLICERIDINE | 4.0 | 1 | 5.26 |
| CHEMBL5083403 | — | — | 1 | 4.64 |
| CHEMBL5075300 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2443262 | OLICERIDINE | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL5083403 | — | IC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL5075300 | — | IC50 | > | 40000.0 | nM | - |