Assay Detail
Binding
CHEMBL5043469
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant full length P-RNAase L (1 to 743 residues)expressed in Escherichia coli BL21 (DE3) assessed as inhibition rate in presence of 2-5A AND ATP/MgCl2 by STD-NMR spectroscopy
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification of Small Molecule Inhibitors of RNase L by Fragment-Based Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.83 | 5.90 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL251254 | HYPEROSIDE | — | 1 | 5.90 |
| CHEMBL164 | MYRICETIN | — | 1 | 3.76 |
| CHEMBL459008 | BUTYLPARABEN | -1.0 | 1 | - |
| CHEMBL487417 | VITEXIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL251254 | HYPEROSIDE | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL164 | MYRICETIN | IC50 | = | 173000.0 | nM | 3.76 |
| CHEMBL459008 | BUTYLPARABEN | Inhibition | - | % | - | |
| CHEMBL487417 | VITEXIN | IC50 | = | 109000.0 | nM | - |