Assay Detail
Binding
CHEMBL5043593
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse uPA using Z-Gly-Gly-Arg-AMC as substrate measured for 15 mins by fluorometric assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Urokinase-type plasminogen activator (CHEMBL1075311) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Disruption of Water Networks is the Cause of Human/Mouse Species Selectivity in Urokinase Plasminogen Activator (uPA) Inhibitors Derived from Hexamethylene Amiloride (HMA).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.69 | 6.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4513418 | — | — | 1 | 6.02 |
| CHEMBL4211423 | — | — | 1 | 5.56 |
| CHEMBL4206764 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4513418 | — | Ki | = | 956.0 | nM | 6.02 |
| CHEMBL4211423 | — | Ki | = | 2768.0 | nM | 5.56 |
| CHEMBL4206764 | — | Ki | = | 3293.0 | nM | 5.48 |