Assay Detail
Functional
CHEMBL5043601
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Antiviral activity against Influenza A virus A/Puerto Rico/8/34(H1N1) strain infected in MDCK cells assessed as reduction in viral infection incubated for 48 hrs by crystal violet staining based assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Lead Optimization of Influenza Virus RNA Polymerase Inhibitors Targeting PA-PB1 Interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.85 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4297215 | BALOXAVIR | 2.0 | 1 | 8.15 |
| CHEMBL5088181 | — | — | 1 | 7.17 |
| CHEMBL5072629 | — | — | 1 | 7.14 |
| CHEMBL1200340 | OSELTAMIVIR PHOSPHATE | 4.0 | 1 | 4.94 |
| CHEMBL221722 | FAVIPIRAVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4297215 | BALOXAVIR | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5088181 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5072629 | — | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL1200340 | OSELTAMIVIR PHOSPHATE | EC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL221722 | FAVIPIRAVIR | EC50 | - | — | - |