Assay Detail
Binding
CHEMBL5043750
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse SGK1 in presence 500 uM presence of ATP
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase Sgk1 (CHEMBL3988610) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.63 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5094921 | — | — | 1 | 6.77 |
| CHEMBL3355029 | — | — | 1 | 6.60 |
| CHEMBL5082336 | — | — | 1 | 6.53 |
| CHEMBL5093302 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5094921 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL3355029 | — | IC50 | = | 253.0 | nM | 6.60 |
| CHEMBL5082336 | — | IC50 | = | 294.0 | nM | 6.53 |
| CHEMBL5093302 | — | IC50 | - | — | - |