Assay Detail
Binding
CHEMBL5043751
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Inhibition of rat SGK1 in presence 500 uM presence of ATP
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.54 | 6.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5094921 | — | — | 1 | 6.65 |
| CHEMBL5082336 | — | — | 1 | 6.52 |
| CHEMBL3355029 | — | — | 1 | 6.45 |
| CHEMBL5093302 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5094921 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL5082336 | — | IC50 | = | 303.0 | nM | 6.52 |
| CHEMBL3355029 | — | IC50 | = | 358.0 | nM | 6.45 |
| CHEMBL5093302 | — | IC50 | - | — | - |