Assay Detail
Binding
CHEMBL5043884
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Inhibition of human recombinant HDAC1 using Boc-Lys(acetyl)-AMC substrate incubated for 2 hrs by fluorescence based assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent Hydrazide-Based HDAC Inhibitors with a Superior Pharmacokinetic Profile for Efficient Treatment of Acute Myeloid Leukemia In Vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 8.03 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5083249 | — | — | 1 | 8.52 |
| CHEMBL5078985 | — | — | 1 | 8.45 |
| CHEMBL5087431 | — | — | 1 | 8.42 |
| CHEMBL5086141 | — | — | 1 | 8.41 |
| CHEMBL5080511 | — | — | 1 | 8.33 |
| CHEMBL4597954 | — | — | 1 | 8.29 |
| CHEMBL5093099 | — | — | 1 | 8.13 |
| CHEMBL5083475 | — | — | 1 | 8.11 |
| CHEMBL5084347 | — | — | 1 | 8.10 |
| CHEMBL5093836 | — | — | 1 | 8.09 |
| CHEMBL5086924 | — | — | 1 | 8.06 |
| CHEMBL5089712 | — | — | 1 | 8.05 |
| CHEMBL5084847 | — | — | 1 | 8.01 |
| CHEMBL5073909 | — | — | 1 | 7.97 |
| CHEMBL5081353 | — | — | 1 | 7.95 |
| CHEMBL5089744 | — | — | 1 | 7.93 |
| CHEMBL4526892 | — | — | 1 | 7.93 |
| CHEMBL5089258 | — | — | 1 | 7.89 |
| CHEMBL5087971 | — | — | 1 | 7.86 |
| CHEMBL5073024 | — | — | 1 | 7.86 |
| CHEMBL5074837 | — | — | 1 | 7.79 |
| CHEMBL5075150 | — | — | 1 | 7.77 |
| CHEMBL5075425 | — | — | 1 | 7.68 |
| CHEMBL5076715 | — | — | 1 | 7.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5083249 | — | IC50 | = | 3.01 | nM | 8.52 |
| CHEMBL5078985 | — | IC50 | = | 3.52 | nM | 8.45 |
| CHEMBL5087431 | — | IC50 | = | 3.79 | nM | 8.42 |
| CHEMBL5086141 | — | IC50 | = | 3.91 | nM | 8.41 |
| CHEMBL5080511 | — | IC50 | = | 4.66 | nM | 8.33 |
| CHEMBL4597954 | — | IC50 | = | 5.17 | nM | 8.29 |
| CHEMBL5093099 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL5083475 | — | IC50 | = | 7.85 | nM | 8.11 |
| CHEMBL5084347 | — | IC50 | = | 7.98 | nM | 8.10 |
| CHEMBL5093836 | — | IC50 | = | 8.22 | nM | 8.09 |
| CHEMBL5086924 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL5089712 | — | IC50 | = | 8.91 | nM | 8.05 |
| CHEMBL5084847 | — | IC50 | = | 9.73 | nM | 8.01 |
| CHEMBL5073909 | — | IC50 | = | 10.73 | nM | 7.97 |
| CHEMBL5081353 | — | IC50 | = | 11.28 | nM | 7.95 |
| CHEMBL5089744 | — | IC50 | = | 11.71 | nM | 7.93 |
| CHEMBL4526892 | — | IC50 | = | 11.81 | nM | 7.93 |
| CHEMBL5089258 | — | IC50 | = | 12.93 | nM | 7.89 |
| CHEMBL5087971 | — | IC50 | = | 13.76 | nM | 7.86 |
| CHEMBL5073024 | — | IC50 | = | 13.7 | nM | 7.86 |
| CHEMBL5074837 | — | IC50 | = | 16.15 | nM | 7.79 |
| CHEMBL5075150 | — | IC50 | = | 17.1 | nM | 7.77 |
| CHEMBL5075425 | — | IC50 | = | 20.76 | nM | 7.68 |
| CHEMBL5076715 | — | IC50 | = | 58.31 | nM | 7.23 |