Assay Detail
Binding
CHEMBL5043886
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Inhibition of human recombinant HDAC2 using Boc-Lys(acetyl)-AMC substrate incubated for 2 hrs by fluorescence based assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent Hydrazide-Based HDAC Inhibitors with a Superior Pharmacokinetic Profile for Efficient Treatment of Acute Myeloid Leukemia In Vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.46 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5078985 | — | — | 1 | 7.82 |
| CHEMBL5080511 | — | — | 1 | 7.79 |
| CHEMBL5086141 | — | — | 1 | 7.79 |
| CHEMBL5087431 | — | — | 1 | 7.77 |
| CHEMBL5083249 | — | — | 1 | 7.73 |
| CHEMBL5083475 | — | — | 1 | 7.62 |
| CHEMBL5093099 | — | — | 1 | 7.58 |
| CHEMBL5089712 | — | — | 1 | 7.55 |
| CHEMBL5093836 | — | — | 1 | 7.55 |
| CHEMBL5084347 | — | — | 1 | 7.52 |
| CHEMBL5075425 | — | — | 1 | 7.52 |
| CHEMBL5086924 | — | — | 1 | 7.51 |
| CHEMBL5081353 | — | — | 1 | 7.48 |
| CHEMBL5089744 | — | — | 1 | 7.45 |
| CHEMBL5075150 | — | — | 1 | 7.40 |
| CHEMBL5084847 | — | — | 1 | 7.38 |
| CHEMBL5074837 | — | — | 1 | 7.38 |
| CHEMBL5087971 | — | — | 1 | 7.34 |
| CHEMBL4597954 | — | — | 1 | 7.30 |
| CHEMBL5089258 | — | — | 1 | 7.28 |
| CHEMBL5073909 | — | — | 1 | 7.24 |
| CHEMBL5073024 | — | — | 1 | 7.22 |
| CHEMBL4526892 | — | — | 1 | 7.02 |
| CHEMBL5076715 | — | — | 1 | 6.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5078985 | — | IC50 | = | 15.14 | nM | 7.82 |
| CHEMBL5080511 | — | IC50 | = | 16.35 | nM | 7.79 |
| CHEMBL5086141 | — | IC50 | = | 16.06 | nM | 7.79 |
| CHEMBL5087431 | — | IC50 | = | 16.92 | nM | 7.77 |
| CHEMBL5083249 | — | IC50 | = | 18.54 | nM | 7.73 |
| CHEMBL5083475 | — | IC50 | = | 23.75 | nM | 7.62 |
| CHEMBL5093099 | — | IC50 | = | 26.13 | nM | 7.58 |
| CHEMBL5089712 | — | IC50 | = | 28.08 | nM | 7.55 |
| CHEMBL5093836 | — | IC50 | = | 27.89 | nM | 7.55 |
| CHEMBL5084347 | — | IC50 | = | 30.51 | nM | 7.52 |
| CHEMBL5075425 | — | IC50 | = | 30.14 | nM | 7.52 |
| CHEMBL5086924 | — | IC50 | = | 30.94 | nM | 7.51 |
| CHEMBL5081353 | — | IC50 | = | 33.39 | nM | 7.48 |
| CHEMBL5089744 | — | IC50 | = | 35.77 | nM | 7.45 |
| CHEMBL5075150 | — | IC50 | = | 39.63 | nM | 7.40 |
| CHEMBL5084847 | — | IC50 | = | 42.03 | nM | 7.38 |
| CHEMBL5074837 | — | IC50 | = | 41.42 | nM | 7.38 |
| CHEMBL5087971 | — | IC50 | = | 46.06 | nM | 7.34 |
| CHEMBL4597954 | — | IC50 | = | 49.5 | nM | 7.30 |
| CHEMBL5089258 | — | IC50 | = | 52.7 | nM | 7.28 |
| CHEMBL5073909 | — | IC50 | = | 57.31 | nM | 7.24 |
| CHEMBL5073024 | — | IC50 | = | 59.64 | nM | 7.22 |
| CHEMBL4526892 | — | IC50 | = | 95.45 | nM | 7.02 |
| CHEMBL5076715 | — | IC50 | = | 185.7 | nM | 6.73 |