Assay Detail
Binding
CHEMBL5044548
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Inhibition of SARS-CoV-2 3CL protease
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and in vitro evaluation of novel SARS-CoV-2 3CL<sup>pro</sup> covalent inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.65 | 7.70 |
| Ki | 2 | 9.57 | 9.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4802214 | LUFOTRELVIR | 3.0 | 1 | 9.57 |
| CHEMBL4777223 | PF-00835231 | -1.0 | 1 | 9.57 |
| CHEMBL4867191 | — | — | 1 | 7.70 |
| CHEMBL1908391 | MASITINIB | 3.0 | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4802214 | LUFOTRELVIR | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL4777223 | PF-00835231 | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL4867191 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1908391 | MASITINIB | IC50 | = | 2500.0 | nM | 5.60 |