Assay Detail
Binding
CHEMBL5044661
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human HDAC1 expressed in baculovirus expression system using Ac-Leu-Gly-Lys (Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by fluorescence microtiter plate reader assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel Histone Deacetylase 6 (HDAC6) Inhibitors with Enhanced Antitumor Immunity of Anti-PD-L1 Immunotherapy in Melanoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.47 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.54 |
| CHEMBL511749 | — | — | 1 | 6.58 |
| CHEMBL5093832 | — | — | 1 | 5.50 |
| CHEMBL5079482 | — | — | 1 | 5.49 |
| CHEMBL5080669 | — | — | 1 | 5.41 |
| CHEMBL5076163 | — | — | 1 | 5.36 |
| CHEMBL5092352 | — | — | 1 | 5.33 |
| CHEMBL5069541 | — | — | 1 | 5.30 |
| CHEMBL5082644 | — | — | 1 | 5.29 |
| CHEMBL5093602 | — | — | 1 | 5.03 |
| CHEMBL5070026 | — | — | 1 | 5.01 |
| CHEMBL5077674 | — | — | 1 | 4.98 |
| CHEMBL5085871 | — | — | 1 | 4.95 |
| CHEMBL5079646 | — | — | 1 | 4.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL511749 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5093832 | — | IC50 | = | 3190.0 | nM | 5.50 |
| CHEMBL5079482 | — | IC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL5080669 | — | IC50 | = | 3930.0 | nM | 5.41 |
| CHEMBL5076163 | — | IC50 | = | 4340.0 | nM | 5.36 |
| CHEMBL5092352 | — | IC50 | = | 4660.0 | nM | 5.33 |
| CHEMBL5069541 | — | IC50 | = | 5030.0 | nM | 5.30 |
| CHEMBL5082644 | — | IC50 | = | 5130.0 | nM | 5.29 |
| CHEMBL5093602 | — | IC50 | = | 9320.0 | nM | 5.03 |
| CHEMBL5070026 | — | IC50 | = | 9790.0 | nM | 5.01 |
| CHEMBL5077674 | — | IC50 | = | 10430.0 | nM | 4.98 |
| CHEMBL5085871 | — | IC50 | = | 11210.0 | nM | 4.95 |
| CHEMBL5079646 | — | IC50 | = | 13520.0 | nM | 4.87 |