Assay Detail
Binding
CHEMBL5044663
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human N-terminal GST tagged HDAC6 expressed in baculovirus infected Sf9 insect cells using Ac-Leu-Gly-Lys (Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by fluorescence microtiter plate reader assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel Histone Deacetylase 6 (HDAC6) Inhibitors with Enhanced Antitumor Immunity of Anti-PD-L1 Immunotherapy in Melanoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.23 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL511749 | — | — | 1 | 7.75 |
| CHEMBL5093832 | — | — | 1 | 7.51 |
| CHEMBL5092352 | — | — | 1 | 7.32 |
| CHEMBL5093602 | — | — | 1 | 7.17 |
| CHEMBL5085871 | — | — | 1 | 7.12 |
| CHEMBL5080669 | — | — | 1 | 6.23 |
| CHEMBL5094432 | — | — | 1 | 6.21 |
| CHEMBL5083767 | — | — | 1 | 6.21 |
| CHEMBL5082644 | — | — | 1 | 6.19 |
| CHEMBL5086629 | — | — | 1 | 6.15 |
| CHEMBL5085919 | — | — | 1 | 6.12 |
| CHEMBL5085234 | — | — | 1 | 6.11 |
| CHEMBL5075320 | — | — | 1 | 6.10 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.07 |
| CHEMBL5076163 | — | — | 1 | 6.04 |
| CHEMBL5093312 | — | — | 1 | 6.03 |
| CHEMBL5077333 | — | — | 1 | 6.01 |
| CHEMBL5069541 | — | — | 1 | 5.96 |
| CHEMBL5079482 | — | — | 1 | 5.68 |
| CHEMBL5077674 | — | — | 1 | 5.05 |
| CHEMBL5070026 | — | — | 1 | 5.03 |
| CHEMBL5079646 | — | — | 1 | 5.02 |
| CHEMBL5081121 | — | — | 1 | - |
| CHEMBL5072579 | — | — | 1 | - |
| CHEMBL5078614 | — | — | 1 | - |
| CHEMBL5078008 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL511749 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5093832 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL5092352 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL5093602 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5085871 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL5080669 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL5094432 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL5083767 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL5082644 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL5086629 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL5085919 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL5085234 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL5075320 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL5076163 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL5093312 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL5077333 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL5069541 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL5079482 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5077674 | — | IC50 | = | 8810.0 | nM | 5.05 |
| CHEMBL5070026 | — | IC50 | = | 9330.0 | nM | 5.03 |
| CHEMBL5079646 | — | IC50 | = | 9530.0 | nM | 5.02 |
| CHEMBL5081121 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5072579 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5078614 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5078008 | — | IC50 | > | 10000.0 | nM | - |