Assay Detail
Functional
CHEMBL5044670
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Antiproliferative activity against mouse B16-F10 cells assessed as inhibition of cell proliferation measured after 48 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | B16-F10 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Histone Deacetylase 6 (HDAC6) Inhibitors with Enhanced Antitumor Immunity of Anti-PD-L1 Immunotherapy in Melanoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.28 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5093832 | — | — | 1 | 5.64 |
| CHEMBL5085871 | — | — | 1 | 5.53 |
| CHEMBL5080669 | — | — | 1 | 5.45 |
| CHEMBL5079482 | — | — | 1 | 5.29 |
| CHEMBL5092352 | — | — | 1 | 5.28 |
| CHEMBL5077674 | — | — | 1 | 5.20 |
| CHEMBL5070026 | — | — | 1 | 5.12 |
| CHEMBL511749 | — | — | 1 | 5.03 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 4.95 |
| CHEMBL5082644 | — | — | 1 | - |
| CHEMBL5093602 | — | — | 1 | - |
| CHEMBL5079646 | — | — | 1 | - |
| CHEMBL5076163 | — | — | 1 | - |
| CHEMBL5069541 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5093832 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL5085871 | — | IC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL5080669 | — | IC50 | = | 3520.0 | nM | 5.45 |
| CHEMBL5079482 | — | IC50 | = | 5090.0 | nM | 5.29 |
| CHEMBL5092352 | — | IC50 | = | 5260.0 | nM | 5.28 |
| CHEMBL5077674 | — | IC50 | = | 6370.0 | nM | 5.20 |
| CHEMBL5070026 | — | IC50 | = | 7620.0 | nM | 5.12 |
| CHEMBL511749 | — | IC50 | = | 9410.0 | nM | 5.03 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 11360.0 | nM | 4.95 |
| CHEMBL5082644 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5093602 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5079646 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5076163 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5069541 | — | IC50 | > | 10000.0 | nM | - |