Assay Detail
Functional
CHEMBL5045209
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
62
Total Activities
62
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Based Design and Synthesis of N-Substituted 3-Amino-β-Carboline Derivatives as Potent αβ-Tubulin Degradation Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 62 | 7.17 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5081610 | — | — | 1 | 8.30 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.80 |
| CHEMBL5085440 | — | — | 1 | 7.72 |
| CHEMBL5087832 | — | — | 1 | 7.41 |
| CHEMBL5088386 | — | — | 1 | 7.39 |
| CHEMBL5090962 | — | — | 1 | 7.37 |
| CHEMBL5083236 | — | — | 1 | 7.35 |
| CHEMBL5086008 | — | — | 1 | 7.34 |
| CHEMBL1808759 | — | — | 1 | 7.29 |
| CHEMBL5085897 | — | — | 1 | 7.25 |
| CHEMBL5088343 | — | — | 1 | 7.24 |
| CHEMBL5089875 | — | — | 1 | 7.23 |
| CHEMBL5084682 | — | — | 1 | 7.20 |
| CHEMBL5094583 | — | — | 1 | 7.18 |
| CHEMBL5075051 | — | — | 1 | 7.17 |
| CHEMBL5080106 | — | — | 1 | 7.15 |
| CHEMBL5085138 | — | — | 1 | 7.09 |
| CHEMBL5079490 | — | — | 1 | 7.08 |
| CHEMBL5081979 | — | — | 1 | 7.03 |
| CHEMBL5074579 | — | — | 1 | 7.03 |
| CHEMBL5088801 | — | — | 1 | 6.68 |
| CHEMBL5087670 | — | — | 1 | 6.66 |
| CHEMBL5088534 | — | — | 1 | 6.58 |
| CHEMBL5088090 | — | — | 1 | 6.38 |
| CHEMBL5087887 | — | — | 1 | 6.30 |
| CHEMBL5085319 | — | — | 1 | - |
| CHEMBL5075988 | — | — | 1 | - |
| CHEMBL5087135 | — | — | 1 | - |
| CHEMBL5084164 | — | — | 1 | - |
| CHEMBL1808761 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5081610 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL107 | COLCHICINE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5085440 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5087832 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL5088386 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL5090962 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL5083236 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5086008 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL1808759 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL5085897 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL5088343 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL5089875 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL5084682 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL5094583 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL5075051 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5080106 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL5085138 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL5079490 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL5081979 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL5074579 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL5088801 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL5087670 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL5088534 | — | IC50 | = | 266.0 | nM | 6.58 |
| CHEMBL5088090 | — | IC50 | = | 412.0 | nM | 6.38 |
| CHEMBL5087887 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5088597 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL5089297 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL5071014 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL5092383 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL5081874 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL5083915 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL1668723 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL5089513 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL5089498 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL1668725 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL5080737 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL5079661 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL5081235 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL5089317 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL5080673 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL5075945 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL5073687 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL5090556 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL5090766 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL5087171 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL1808761 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL5084164 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL5087135 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL5075988 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL5085319 | — | IC50 | > | 500.0 | nM | - |