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Assay Detail

CHEMBL5045211

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Functional
Antiproliferative activity against human NCI-H460 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
ChEMBL ↗
62
Total Activities
62
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type NCI-H460
Confidence 1 — Organism
Curated By Autocuration

Target

NCI-H460 (CHEMBL396) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Structure-Based Design and Synthesis of N-Substituted 3-Amino-β-Carboline Derivatives as Potent αβ-Tubulin Degradation Agents.
Li Y, Liu Y, Zhu Z, Yan W, Zhang C, Yang Z, Bai P, Tang M, Shi M, He W, Fu S, Liu J, Han K, Li J, Xie L, Ye H, Yang J, Chen L.
J Med Chem (2022) 65 : 2675 -2693
PubMed 35084853 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 62 7.05 7.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL107 COLCHICINE 4.0 1 7.92
CHEMBL5081610 — — 1 7.85
CHEMBL5075051 — — 1 7.51
CHEMBL5088386 — — 1 7.36
CHEMBL5090962 — — 1 7.33
CHEMBL5085138 — — 1 7.33
CHEMBL5086008 — — 1 7.32
CHEMBL5080106 — — 1 7.30
CHEMBL5088343 — — 1 7.28
CHEMBL1808759 — — 1 7.21
CHEMBL5085440 — — 1 7.17
CHEMBL5084682 — — 1 7.13
CHEMBL5079490 — — 1 7.13
CHEMBL5087832 — — 1 7.12
CHEMBL5074579 — — 1 7.06
CHEMBL5089875 — — 1 6.98
CHEMBL5085897 — — 1 6.78
CHEMBL5083236 — — 1 6.65
CHEMBL5081979 — — 1 6.63
CHEMBL5087670 — — 1 6.50
CHEMBL5088801 — — 1 6.48
CHEMBL5083915 — — 1 6.47
CHEMBL5094583 — — 1 6.47
CHEMBL5080737 — — 1 6.30
CHEMBL5073687 — — 1 -
CHEMBL5085319 — — 1 -
CHEMBL5089513 — — 1 -
CHEMBL1668723 — — 1 -
CHEMBL5075988 — — 1 -
CHEMBL5092383 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL107 COLCHICINE IC50 = 12.0 nM 7.92
CHEMBL5081610 — IC50 = 14.0 nM 7.85
CHEMBL5075051 — IC50 = 31.0 nM 7.51
CHEMBL5088386 — IC50 = 44.0 nM 7.36
CHEMBL5090962 — IC50 = 47.0 nM 7.33
CHEMBL5085138 — IC50 = 47.0 nM 7.33
CHEMBL5086008 — IC50 = 48.0 nM 7.32
CHEMBL5080106 — IC50 = 50.0 nM 7.30
CHEMBL5088343 — IC50 = 52.0 nM 7.28
CHEMBL1808759 — IC50 = 62.0 nM 7.21
CHEMBL5085440 — IC50 = 67.0 nM 7.17
CHEMBL5084682 — IC50 = 74.0 nM 7.13
CHEMBL5079490 — IC50 = 74.0 nM 7.13
CHEMBL5087832 — IC50 = 76.0 nM 7.12
CHEMBL5074579 — IC50 = 87.0 nM 7.06
CHEMBL5089875 — IC50 = 105.0 nM 6.98
CHEMBL5085897 — IC50 = 165.0 nM 6.78
CHEMBL5083236 — IC50 = 222.0 nM 6.65
CHEMBL5081979 — IC50 = 234.0 nM 6.63
CHEMBL5087670 — IC50 = 313.0 nM 6.50
CHEMBL5088801 — IC50 = 333.0 nM 6.48
CHEMBL5083915 — IC50 = 340.0 nM 6.47
CHEMBL5094583 — IC50 = 342.0 nM 6.47
CHEMBL5080737 — IC50 = 500.0 nM 6.30
CHEMBL5089317 — IC50 > 500.0 nM -
CHEMBL5081235 — IC50 > 500.0 nM -
CHEMBL5088597 — IC50 > 500.0 nM -
CHEMBL5089297 — IC50 > 500.0 nM -
CHEMBL5071014 — IC50 > 500.0 nM -
CHEMBL5087135 — IC50 > 500.0 nM -
CHEMBL5088090 — IC50 > 500.0 nM -
CHEMBL5092980 — IC50 > 500.0 nM -
CHEMBL1808771 — IC50 > 500.0 nM -
CHEMBL5094942 — IC50 > 500.0 nM -
CHEMBL5081874 — IC50 > 500.0 nM -
CHEMBL5069794 — IC50 > 500.0 nM -
CHEMBL5078377 — IC50 > 500.0 nM -
CHEMBL5080673 — IC50 > 500.0 nM -
CHEMBL5075945 — IC50 > 500.0 nM -
CHEMBL5084164 — IC50 > 500.0 nM -
CHEMBL5090556 — IC50 > 500.0 nM -
CHEMBL5090766 — IC50 > 500.0 nM -
CHEMBL5087171 — IC50 > 500.0 nM -
CHEMBL1808761 — IC50 > 500.0 nM -
CHEMBL5092383 — IC50 > 500.0 nM -
CHEMBL5075988 — IC50 > 500.0 nM -
CHEMBL1668723 — IC50 > 500.0 nM -
CHEMBL5089513 — IC50 > 500.0 nM -
CHEMBL5085319 — IC50 > 500.0 nM -
CHEMBL5073687 — IC50 > 500.0 nM -