Assay Detail
Functional
CHEMBL5045218
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity in human A549T assessed as inhibition in cell growth measured after 24 hrs by MTT assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549/TR |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Based Design and Synthesis of N-Substituted 3-Amino-β-Carboline Derivatives as Potent αβ-Tubulin Degradation Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.65 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5081610 | — | — | 1 | 7.20 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5081610 | — | IC50 | = | 63.8 | nM | 7.20 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 802.0 | nM | 6.10 |