Assay Detail
Binding
CHEMBL5045455
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Binding affinity to Candida albicans Fructose-1,6-Bisphosphate Aldolase assessed as inhibition constant incubated for 12 to 40 mins by NADH-linked enzymatic assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Candida albicans |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of <i>Candidiasis</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.26 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5078831 | — | — | 1 | 7.24 |
| CHEMBL5075692 | — | — | 1 | 6.31 |
| CHEMBL5086795 | — | — | 1 | 6.25 |
| CHEMBL5075467 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5078831 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL5075692 | — | Ki | = | 486.0 | nM | 6.31 |
| CHEMBL5086795 | — | Ki | = | 559.0 | nM | 6.25 |
| CHEMBL5075467 | — | Ki | = | 5959.0 | nM | 5.22 |