Assay Detail
Binding
CHEMBL5045529
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at STING in human THP1 Dual cells assessed as IRF reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | H69AR |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Stimulator of interferon genes protein (CHEMBL4523377) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Non-Nucleotide Small-Molecule STING Agonists <i>via</i> Chemotype Hybridization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 4.95 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4438309 | — | — | 1 | 7.46 |
| CHEMBL5086556 | — | — | 1 | 6.28 |
| CHEMBL5089074 | — | — | 1 | 5.85 |
| CHEMBL5086226 | — | — | 1 | 5.77 |
| CHEMBL5079595 | — | — | 1 | 5.43 |
| CHEMBL5088451 | — | — | 1 | 4.89 |
| CHEMBL4776666 | — | — | 1 | 4.43 |
| CHEMBL5080916 | — | — | 1 | 4.32 |
| CHEMBL5077683 | — | — | 1 | 4.24 |
| CHEMBL5090440 | — | — | 1 | 4.23 |
| CHEMBL4528146 | — | — | 1 | 4.11 |
| CHEMBL5081567 | — | — | 1 | 4.11 |
| CHEMBL5082707 | — | — | 1 | 4.10 |
| CHEMBL5082881 | — | — | 1 | 4.02 |
| CHEMBL5089143 | — | — | 1 | - |
| CHEMBL71263 | VADIMEZAN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4438309 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL5086556 | — | EC50 | = | 530.0 | nM | 6.28 |
| CHEMBL5089074 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5086226 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5079595 | — | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL5088451 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4776666 | — | EC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL5080916 | — | EC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL5077683 | — | EC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL5090440 | — | EC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL4528146 | — | EC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL5081567 | — | EC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL5082707 | — | EC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL5082881 | — | EC50 | = | 96000.0 | nM | 4.02 |
| CHEMBL5089143 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL71263 | VADIMEZAN | EC50 | > | 100000.0 | nM | - |