Assay Detail
Binding
CHEMBL5045533
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at STING in human THP1-Dual cells assessed as NF-kappaB reporter activation incubated for 20 hrs by quanti-blue SEAP reporter gene assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | H69AR |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Stimulator of interferon genes protein (CHEMBL4523377) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Non-Nucleotide Small-Molecule STING Agonists <i>via</i> Chemotype Hybridization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 5.37 | 7.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4438309 | — | — | 1 | 7.26 |
| CHEMBL5086556 | — | — | 1 | 6.40 |
| CHEMBL5086226 | — | — | 1 | 5.85 |
| CHEMBL5089074 | — | — | 1 | 5.75 |
| CHEMBL5079595 | — | — | 1 | 5.46 |
| CHEMBL4528146 | — | — | 1 | 5.35 |
| CHEMBL5088451 | — | — | 1 | 4.82 |
| CHEMBL5080916 | — | — | 1 | 4.43 |
| CHEMBL4776666 | — | — | 1 | 4.22 |
| CHEMBL5077683 | — | — | 1 | 4.20 |
| CHEMBL5089143 | — | — | 1 | - |
| CHEMBL5082881 | — | — | 1 | - |
| CHEMBL71263 | VADIMEZAN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4438309 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5086556 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5086226 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5089074 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5079595 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4528146 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL5088451 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL5080916 | — | EC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL4776666 | — | EC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL5077683 | — | EC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL5089143 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL5082881 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL71263 | VADIMEZAN | EC50 | > | 100000.0 | nM | - |