Assay Detail
Binding
CHEMBL5045537
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of fluorescein-labelled probe from human cytoplasmic domain of STING G230A/R293Q double mutant (155 to 341 residues) by time-resolved FRET-based competition binding assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Stimulator of interferon genes protein (CHEMBL4523377) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Non-Nucleotide Small-Molecule STING Agonists <i>via</i> Chemotype Hybridization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.64 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4438309 | — | — | 1 | 8.41 |
| CHEMBL4776666 | — | — | 1 | 8.14 |
| CHEMBL5080916 | — | — | 1 | 6.33 |
| CHEMBL5081567 | — | — | 1 | 6.24 |
| CHEMBL4528146 | — | — | 1 | 5.89 |
| CHEMBL5082881 | — | — | 1 | 5.77 |
| CHEMBL5082361 | — | — | 1 | 5.31 |
| CHEMBL5082707 | — | — | 1 | 5.30 |
| CHEMBL5090440 | — | — | 1 | 5.28 |
| CHEMBL5077683 | — | — | 1 | 4.96 |
| CHEMBL5089143 | — | — | 1 | 4.85 |
| CHEMBL5091795 | — | — | 1 | 4.64 |
| CHEMBL5088178 | — | — | 1 | 4.62 |
| CHEMBL5092039 | — | — | 1 | 4.47 |
| CHEMBL5078116 | — | — | 1 | 4.39 |
| CHEMBL71263 | VADIMEZAN | 3.0 | 1 | - |
| CHEMBL5079595 | — | — | 1 | - |
| CHEMBL5086226 | — | — | 1 | - |
| CHEMBL5086556 | — | — | 1 | - |
| CHEMBL5076859 | — | — | 1 | - |
| CHEMBL5082150 | — | — | 1 | - |
| CHEMBL5089074 | — | — | 1 | - |
| CHEMBL5088451 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4438309 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL4776666 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL5080916 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL5081567 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4528146 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5082881 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5082361 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL5082707 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL5090440 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL5077683 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5089143 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL5091795 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL5088178 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL5092039 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL5078116 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL71263 | VADIMEZAN | IC50 | > | 100000.0 | nM | - |
| CHEMBL5079595 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5086226 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5086556 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5076859 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5082150 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5089074 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5088451 | — | IC50 | > | 100000.0 | nM | - |