Assay Detail
Binding
CHEMBL5045758
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant C terminal hFc tagged FLT3 (Asn27-Ser543 residues) expressed in HEK293 cells incubated for 1 hrs by HTRF KinEASE TK
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of 2-Aminopyrimidine Derivatives as FLT3 Kinase Inhibitors with High Selectivity over c-KIT.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.33 | 8.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5089164 | — | — | 1 | 8.45 |
| CHEMBL5092606 | — | — | 1 | 8.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5089164 | — | IC50 | = | 3.56 | nM | 8.45 |
| CHEMBL5092606 | — | IC50 | = | 6.25 | nM | 8.20 |