Assay Detail
Functional
CHEMBL5045874
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MIA PaCa-2 cells assessed as inhibition of cell growth incubated for overnight in glucose-containing medium followed by compound addition and measured after 7 days by MTT assay
31
Total Activities
31
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Multiparameter Optimization of Oxidative Phosphorylation Inhibitors for the Treatment of Pancreatic Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.54 | 8.05 |
| GI50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5082384 | — | — | 1 | 8.05 |
| CHEMBL5091697 | — | — | 1 | 7.96 |
| CHEMBL5085817 | — | — | 1 | 7.89 |
| CHEMBL5070213 | — | — | 1 | 7.80 |
| CHEMBL5089452 | — | — | 1 | 7.58 |
| CHEMBL1614707 | MUBRITINIB | 2.0 | 1 | 7.29 |
| CHEMBL5089080 | — | — | 1 | 7.16 |
| CHEMBL5086830 | — | — | 1 | 7.10 |
| CHEMBL5070305 | — | — | 1 | 6.96 |
| CHEMBL5076092 | — | — | 1 | 6.93 |
| CHEMBL5089602 | — | — | 1 | 6.85 |
| CHEMBL5087697 | — | — | 1 | 6.68 |
| CHEMBL5080585 | — | — | 1 | 6.60 |
| CHEMBL5074728 | — | — | 1 | 6.50 |
| CHEMBL5089686 | — | — | 1 | 6.46 |
| CHEMBL5071629 | — | — | 1 | 6.46 |
| CHEMBL5081510 | — | — | 1 | 6.38 |
| CHEMBL5093824 | — | — | 1 | 6.23 |
| CHEMBL5075768 | — | — | 1 | 6.12 |
| CHEMBL5081152 | — | — | 1 | 6.06 |
| CHEMBL5083966 | — | — | 1 | 6.05 |
| CHEMBL5084328 | — | — | 1 | 6.02 |
| CHEMBL5076904 | — | — | 1 | 5.87 |
| CHEMBL5085157 | — | — | 1 | 5.78 |
| CHEMBL5070365 | — | — | 1 | 5.63 |
| CHEMBL5078977 | — | — | 1 | 5.61 |
| CHEMBL5093413 | — | — | 1 | 5.42 |
| CHEMBL5094836 | — | — | 1 | 5.41 |
| CHEMBL5080432 | — | — | 1 | 4.67 |
| CHEMBL5072551 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5082384 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5091697 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5085817 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL5070213 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5089452 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1614707 | MUBRITINIB | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL5089080 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5086830 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL5070305 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5076092 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL5089602 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5087697 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5080585 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5074728 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL5089686 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL5071629 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL5081510 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL5093824 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL5075768 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5081152 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL5083966 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5084328 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL5076904 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL5085157 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL5070365 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL5078977 | — | IC50 | = | 2460.0 | nM | 5.61 |
| CHEMBL5093413 | — | IC50 | = | 3770.0 | nM | 5.42 |
| CHEMBL5094836 | — | IC50 | = | 3910.0 | nM | 5.41 |
| CHEMBL5080432 | — | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL5072551 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5070773 | — | GI50 | = | 600.0 | nM | - |