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Assay Detail

CHEMBL5045877

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human MIA PaCa-2 cells assessed as inhibition of cell growth incubated for overnight in galactose-containing medium followed by compound addition and measured after 3 days by MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MIA PaCa-2
Confidence 1 — Organism
Curated By Autocuration

Target

MIA PaCa-2 (CHEMBL614725)
Type CELL-LINE
Organism Homo sapiens

Publication

Multiparameter Optimization of Oxidative Phosphorylation Inhibitors for the Treatment of Pancreatic Cancer.
Xue D, Xu Y, Kyani A, Roy J, Dai L, Sun D, Neamati N.
J Med Chem (2022) 65 : 3404 -3419
PubMed 35167303 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 6.83 8.04

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5091697 1 8.04
CHEMBL5082384 1 7.90
CHEMBL5070213 1 7.72
CHEMBL5080585 1 7.30
CHEMBL5089602 1 7.30
CHEMBL5076092 1 7.14
CHEMBL5075768 1 7.00
CHEMBL5074728 1 6.96
CHEMBL5087697 1 6.87
CHEMBL5081510 1 6.85
CHEMBL5089686 1 6.80
CHEMBL5083966 1 6.66
CHEMBL5081152 1 6.64
CHEMBL5085157 1 6.54
CHEMBL5078977 1 6.34
CHEMBL5084328 1 6.23
CHEMBL5094836 1 5.97
CHEMBL5093413 1 5.87
CHEMBL5076904 1 5.64

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5091697 IC50 = 9.1 nM 8.04
CHEMBL5082384 IC50 = 12.6 nM 7.90
CHEMBL5070213 IC50 = 19.0 nM 7.72
CHEMBL5080585 IC50 = 50.0 nM 7.30
CHEMBL5089602 IC50 = 50.0 nM 7.30
CHEMBL5076092 IC50 = 72.4 nM 7.14
CHEMBL5075768 IC50 = 100.0 nM 7.00
CHEMBL5074728 IC50 = 110.0 nM 6.96
CHEMBL5087697 IC50 = 135.1 nM 6.87
CHEMBL5081510 IC50 = 140.0 nM 6.85
CHEMBL5089686 IC50 = 160.0 nM 6.80
CHEMBL5083966 IC50 = 220.0 nM 6.66
CHEMBL5081152 IC50 = 230.0 nM 6.64
CHEMBL5085157 IC50 = 290.0 nM 6.54
CHEMBL5078977 IC50 = 460.0 nM 6.34
CHEMBL5084328 IC50 = 590.0 nM 6.23
CHEMBL5094836 IC50 = 1070.0 nM 5.97
CHEMBL5093413 IC50 = 1350.0 nM 5.87
CHEMBL5076904 IC50 = 2290.0 nM 5.64