Assay Detail
Binding
CHEMBL5045882
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of oxidative phosphorylation complex I in human MIA PaCa-2 cells assessed as reduction in NAD+/NADH ratio incubated for 48 hrs in glucose-containing medium by NAD/NADH-Glo assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Multiparameter Optimization of Oxidative Phosphorylation Inhibitors for the Treatment of Pancreatic Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.84 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5082384 | — | — | 1 | 8.49 |
| CHEMBL5091697 | — | — | 1 | 8.44 |
| CHEMBL5070213 | — | — | 1 | 7.64 |
| CHEMBL5076092 | — | — | 1 | 7.47 |
| CHEMBL5087697 | — | — | 1 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5082384 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL5091697 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL5070213 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5076092 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL5087697 | — | IC50 | = | 67.5 | nM | 7.17 |