Assay Detail
Functional
CHEMBL5045941
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Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by CellTiter 96 AQueous One Solution Cell Proliferation assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.30 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4647810 | ELIMUSERTIB | 1.0 | 1 | 7.05 |
| CHEMBL2325697 | — | — | 1 | 6.16 |
| CHEMBL4285417 | CERALASERTIB | 3.0 | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4647810 | ELIMUSERTIB | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2325697 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4285417 | CERALASERTIB | IC50 | = | 2000.0 | nM | 5.70 |