Assay Detail
Binding
CHEMBL5046414
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ERN1 (unknown origin) incubated for 1 hr by qPCR analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase/endoribonuclease IRE1 (CHEMBL1163101) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of New Imidazo[2,1-<i>b</i>]thiazole Derivatives as Potent Pan-RAF Inhibitors with Promising <i>In Vitro</i> and <i>In Vivo</i> Anti-melanoma Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.94 | 5.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5083036 | — | — | 1 | 5.02 |
| CHEMBL5086749 | — | — | 1 | 4.99 |
| CHEMBL5087577 | — | — | 1 | 4.95 |
| CHEMBL5081210 | — | — | 1 | 4.80 |
| CHEMBL5073858 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5083036 | — | IC50 | = | 9540.0 | nM | 5.02 |
| CHEMBL5086749 | — | IC50 | = | 10250.0 | nM | 4.99 |
| CHEMBL5087577 | — | IC50 | = | 11320.0 | nM | 4.95 |
| CHEMBL5081210 | — | IC50 | = | 15650.0 | nM | 4.80 |
| CHEMBL5073858 | — | IC50 | > | 20000.0 | nM | - |