Assay Detail
Binding
CHEMBL5046418
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MAPK8 (unknown origin) incubated for 1 hr by qPCR analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of New Imidazo[2,1-<i>b</i>]thiazole Derivatives as Potent Pan-RAF Inhibitors with Promising <i>In Vitro</i> and <i>In Vivo</i> Anti-melanoma Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.09 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5081210 | — | — | 1 | 6.44 |
| CHEMBL5073858 | — | — | 1 | 6.38 |
| CHEMBL5087577 | — | — | 1 | 6.04 |
| CHEMBL5083036 | — | — | 1 | 5.87 |
| CHEMBL5086749 | — | — | 1 | 5.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5081210 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5073858 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL5087577 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL5083036 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL5086749 | — | IC50 | = | 1870.0 | nM | 5.73 |