Assay Detail
Functional
CHEMBL5046434
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Antiproliferative activity against human Panel ovarian (Carcinoma cell lines) assessed as cell growth inhibition measured after 48 hrs by SRB assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Panel ovarian (Carcinoma cell lines) |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of New Imidazo[2,1-<i>b</i>]thiazole Derivatives as Potent Pan-RAF Inhibitors with Promising <i>In Vitro</i> and <i>In Vivo</i> Anti-melanoma Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.14 | 5.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5086749 | — | — | 1 | 5.53 |
| CHEMBL5075200 | — | — | 1 | 5.45 |
| CHEMBL5073858 | — | — | 1 | 5.42 |
| CHEMBL5079413 | — | — | 1 | 4.92 |
| CHEMBL5083036 | — | — | 1 | 4.85 |
| CHEMBL5087577 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5086749 | — | IC50 | = | 2970.0 | nM | 5.53 |
| CHEMBL5075200 | — | IC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL5073858 | — | IC50 | = | 3850.0 | nM | 5.42 |
| CHEMBL5079413 | — | IC50 | = | 12050.0 | nM | 4.92 |
| CHEMBL5083036 | — | IC50 | = | 14180.0 | nM | 4.85 |
| CHEMBL5087577 | — | IC50 | = | 20670.0 | nM | 4.68 |