Assay Detail
Functional
CHEMBL5046445
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Antiproliferative activity against human UACC-257 cells assessed as cell growth inhibition measured after 48 hrs by SRB assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | UACC-257 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of New Imidazo[2,1-<i>b</i>]thiazole Derivatives as Potent Pan-RAF Inhibitors with Promising <i>In Vitro</i> and <i>In Vivo</i> Anti-melanoma Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.70 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5087577 | — | — | 1 | 6.77 |
| CHEMBL5083036 | — | — | 1 | 6.25 |
| CHEMBL5086749 | — | — | 1 | 5.54 |
| CHEMBL5073858 | — | — | 1 | 5.36 |
| CHEMBL5075200 | — | — | 1 | 5.19 |
| CHEMBL5079413 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5087577 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5083036 | — | IC50 | = | 568.0 | nM | 6.25 |
| CHEMBL5086749 | — | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL5073858 | — | IC50 | = | 4410.0 | nM | 5.36 |
| CHEMBL5075200 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL5079413 | — | IC50 | = | 8210.0 | nM | 5.09 |