Assay Detail
Binding
CHEMBL5046490
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-(R)-(+)7-OH-DPAT from human dopamine D2 receptor expressed in HEK293 cell membranes incubated for 90 mins by microbeta scintillation counting analysis
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Dual-Target μ-Opioid Receptor and Dopamine D<sub>3</sub> Receptor Ligands as Potential Nonaddictive Pharmacotherapeutics for Pain Management.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.07 | 7.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5088070 | — | — | 1 | 7.69 |
| CHEMBL5073754 | — | — | 1 | 7.64 |
| CHEMBL5085974 | — | — | 1 | 7.50 |
| CHEMBL5089655 | — | — | 1 | 7.44 |
| CHEMBL5074399 | — | — | 1 | 7.36 |
| CHEMBL5075990 | — | — | 1 | 7.03 |
| CHEMBL5071238 | — | — | 1 | 6.94 |
| CHEMBL5087543 | — | — | 1 | 6.78 |
| CHEMBL5080654 | — | — | 1 | 6.73 |
| CHEMBL5077645 | — | — | 1 | 5.55 |
| CHEMBL5091775 | — | — | 1 | - |
| CHEMBL5091335 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5088070 | — | Ki | = | 20.3 | nM | 7.69 |
| CHEMBL5073754 | — | Ki | = | 23.1 | nM | 7.64 |
| CHEMBL5085974 | — | Ki | = | 31.3 | nM | 7.50 |
| CHEMBL5089655 | — | Ki | = | 36.3 | nM | 7.44 |
| CHEMBL5074399 | — | Ki | = | 44.2 | nM | 7.36 |
| CHEMBL5075990 | — | Ki | = | 93.7 | nM | 7.03 |
| CHEMBL5071238 | — | Ki | = | 114.0 | nM | 6.94 |
| CHEMBL5087543 | — | Ki | = | 167.0 | nM | 6.78 |
| CHEMBL5080654 | — | Ki | = | 186.0 | nM | 6.73 |
| CHEMBL5077645 | — | Ki | = | 2790.0 | nM | 5.55 |
| CHEMBL5091775 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL5091335 | — | Ki | > | 100000.0 | nM | - |