Assay Detail
Binding
CHEMBL5046587
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of tracer K9 from NLuc fused MARK3 (unknown origin) expressed in HEK293 cells by NanoBRET assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
MAP/microtubule affinity-regulating kinase 3 (CHEMBL5600) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.00 | 6.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5085430 | — | — | 1 | 6.86 |
| CHEMBL3605057 | — | — | 1 | 6.48 |
| CHEMBL5088930 | — | — | 1 | 6.06 |
| CHEMBL5090046 | — | — | 1 | 5.70 |
| CHEMBL3916849 | — | — | 1 | 5.48 |
| CHEMBL5091688 | — | — | 1 | 5.40 |
| CHEMBL5079601 | — | — | 1 | - |
| CHEMBL5084750 | — | — | 1 | - |
| CHEMBL5079920 | — | — | 1 | - |
| CHEMBL5083125 | — | — | 1 | - |
| CHEMBL5087433 | — | — | 1 | - |
| CHEMBL5076165 | — | — | 1 | - |
| CHEMBL5093111 | — | — | 1 | - |
| CHEMBL5072178 | — | — | 1 | - |
| CHEMBL5079149 | — | — | 1 | - |
| CHEMBL5091582 | — | — | 1 | - |
| CHEMBL5087006 | — | — | 1 | - |
| CHEMBL5075360 | — | — | 1 | - |
| CHEMBL5089987 | — | — | 1 | - |
| CHEMBL5085698 | — | — | 1 | - |
| CHEMBL5088682 | — | — | 1 | - |
| CHEMBL5086901 | — | — | 1 | - |
| CHEMBL4446892 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5085430 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL3605057 | — | IC50 | = | 328.0 | nM | 6.48 |
| CHEMBL5088930 | — | IC50 | = | 872.0 | nM | 6.06 |
| CHEMBL5090046 | — | IC50 | = | 2001.0 | nM | 5.70 |
| CHEMBL3916849 | — | IC50 | = | 3333.0 | nM | 5.48 |
| CHEMBL5091688 | — | IC50 | = | 4015.0 | nM | 5.40 |
| CHEMBL5079601 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5084750 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5079920 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5083125 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5087433 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5076165 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5093111 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5072178 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5079149 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5091582 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5087006 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5075360 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5089987 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5085698 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5088682 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5086901 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4446892 | — | IC50 | > | 10000.0 | nM | - |