Assay Detail
Binding
CHEMBL5046608
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 1recombinant human BMPR2 (172 to 734 residues) using myelin basic protein as substrate incubated for 120 mins in presence of [gamma-33P-ATP] by radiometric scintillation assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Bone morphogenetic protein receptor type-2 (CHEMBL5467) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.93 | 6.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5079149 | — | — | 1 | 6.31 |
| CHEMBL5088682 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5079149 | — | IC50 | = | 488.0 | nM | 6.31 |
| CHEMBL5088682 | — | IC50 | = | 2918.0 | nM | 5.54 |