Assay Detail
Binding
CHEMBL5046637
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-ketanserin from human human 5-HT2A receptor transfected in CHO-K1 cells measured after 60 mins by scintillation counting method
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Multifunctional Arylsulfone and Arylsulfonamide-Based Ligands with Prominent Mood-Modulating Activity and Benign Safety Profile, Targeting Neuropsychiatric Symptoms of Dementia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 8.37 | 9.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5084167 | — | — | 1 | 9.61 |
| CHEMBL5076846 | — | — | 1 | 9.19 |
| CHEMBL5090557 | — | — | 1 | 9.16 |
| CHEMBL5088232 | — | — | 1 | 8.82 |
| CHEMBL5092755 | — | — | 1 | 8.77 |
| CHEMBL5077755 | — | — | 1 | 8.77 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 8.72 |
| CHEMBL5089348 | — | — | 1 | 8.71 |
| CHEMBL93240 | METITEPINE | 2.0 | 1 | 8.70 |
| CHEMBL5080719 | — | — | 1 | 8.56 |
| CHEMBL5082267 | — | — | 1 | 8.53 |
| CHEMBL5093017 | — | — | 1 | 8.45 |
| CHEMBL5076882 | — | — | 1 | 8.41 |
| CHEMBL5087742 | — | — | 1 | 8.38 |
| CHEMBL5073337 | — | — | 1 | 8.38 |
| CHEMBL5082182 | — | — | 1 | 8.36 |
| CHEMBL5080305 | — | — | 1 | 8.23 |
| CHEMBL5080955 | — | — | 1 | 8.20 |
| CHEMBL5079536 | — | — | 1 | 8.16 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 7.92 |
| CHEMBL5085390 | — | — | 1 | 7.89 |
| CHEMBL5093250 | — | — | 1 | 7.89 |
| CHEMBL5077178 | — | — | 1 | 7.87 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.64 |
| CHEMBL5083505 | — | — | 1 | 7.40 |
| CHEMBL716 | QUETIAPINE | 4.0 | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5084167 | — | Ki | = | 0.2455 | nM | 9.61 |
| CHEMBL5076846 | — | Ki | = | 0.6457 | nM | 9.19 |
| CHEMBL5090557 | — | Ki | = | 0.6918 | nM | 9.16 |
| CHEMBL5088232 | — | Ki | = | 1.514 | nM | 8.82 |
| CHEMBL5092755 | — | Ki | = | 1.698 | nM | 8.77 |
| CHEMBL5077755 | — | Ki | = | 1.698 | nM | 8.77 |
| CHEMBL715 | OLANZAPINE | Ki | = | 1.905 | nM | 8.72 |
| CHEMBL5089348 | — | Ki | = | 1.95 | nM | 8.71 |
| CHEMBL93240 | METITEPINE | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL5080719 | — | Ki | = | 2.754 | nM | 8.56 |
| CHEMBL5082267 | — | Ki | = | 2.951 | nM | 8.53 |
| CHEMBL5093017 | — | Ki | = | 3.548 | nM | 8.45 |
| CHEMBL5076882 | — | Ki | = | 3.89 | nM | 8.41 |
| CHEMBL5087742 | — | Ki | = | 4.169 | nM | 8.38 |
| CHEMBL5073337 | — | Ki | = | 4.169 | nM | 8.38 |
| CHEMBL5082182 | — | Ki | = | 4.365 | nM | 8.36 |
| CHEMBL5080305 | — | Ki | = | 5.888 | nM | 8.23 |
| CHEMBL5080955 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL5079536 | — | Ki | = | 6.918 | nM | 8.16 |
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 12.02 | nM | 7.92 |
| CHEMBL5085390 | — | Ki | = | 12.88 | nM | 7.89 |
| CHEMBL5093250 | — | Ki | = | 12.88 | nM | 7.89 |
| CHEMBL5077178 | — | Ki | = | 13.49 | nM | 7.87 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 22.91 | nM | 7.64 |
| CHEMBL5083505 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL716 | QUETIAPINE | Ki | = | 120.23 | nM | 6.92 |