Assay Detail
Binding
CHEMBL5046638
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-LSD from human 5-HT6 receptor transfected in CHO-K1 cells measured after 60 mins by scintillation counting method
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Multifunctional Arylsulfone and Arylsulfonamide-Based Ligands with Prominent Mood-Modulating Activity and Benign Safety Profile, Targeting Neuropsychiatric Symptoms of Dementia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 7.62 | 9.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93240 | METITEPINE | 2.0 | 1 | 9.03 |
| CHEMBL5077755 | — | — | 1 | 8.55 |
| CHEMBL5084167 | — | — | 1 | 8.33 |
| CHEMBL5088232 | — | — | 1 | 8.11 |
| CHEMBL5092755 | — | — | 1 | 8.08 |
| CHEMBL5080955 | — | — | 1 | 8.08 |
| CHEMBL5082267 | — | — | 1 | 7.87 |
| CHEMBL5089348 | — | — | 1 | 7.81 |
| CHEMBL5090557 | — | — | 1 | 7.79 |
| CHEMBL5082182 | — | — | 1 | 7.78 |
| CHEMBL5080305 | — | — | 1 | 7.71 |
| CHEMBL5087742 | — | — | 1 | 7.58 |
| CHEMBL5093017 | — | — | 1 | 7.36 |
| CHEMBL5077178 | — | — | 1 | 7.35 |
| CHEMBL5093250 | — | — | 1 | 7.35 |
| CHEMBL5076882 | — | — | 1 | 7.26 |
| CHEMBL5076846 | — | — | 1 | 7.05 |
| CHEMBL5079536 | — | — | 1 | 7.01 |
| CHEMBL5073337 | — | — | 1 | 6.99 |
| CHEMBL5080719 | — | — | 1 | 6.93 |
| CHEMBL5083505 | — | — | 1 | 6.82 |
| CHEMBL5085390 | — | — | 1 | 6.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93240 | METITEPINE | Ki | = | 0.9333 | nM | 9.03 |
| CHEMBL5077755 | — | Ki | = | 2.818 | nM | 8.55 |
| CHEMBL5084167 | — | Ki | = | 4.677 | nM | 8.33 |
| CHEMBL5088232 | — | Ki | = | 7.762 | nM | 8.11 |
| CHEMBL5092755 | — | Ki | = | 8.318 | nM | 8.08 |
| CHEMBL5080955 | — | Ki | = | 8.318 | nM | 8.08 |
| CHEMBL5082267 | — | Ki | = | 13.49 | nM | 7.87 |
| CHEMBL5089348 | — | Ki | = | 15.49 | nM | 7.81 |
| CHEMBL5090557 | — | Ki | = | 16.22 | nM | 7.79 |
| CHEMBL5082182 | — | Ki | = | 16.6 | nM | 7.78 |
| CHEMBL5080305 | — | Ki | = | 19.5 | nM | 7.71 |
| CHEMBL5087742 | — | Ki | = | 26.3 | nM | 7.58 |
| CHEMBL5093017 | — | Ki | = | 43.65 | nM | 7.36 |
| CHEMBL5077178 | — | Ki | = | 44.67 | nM | 7.35 |
| CHEMBL5093250 | — | Ki | = | 44.67 | nM | 7.35 |
| CHEMBL5076882 | — | Ki | = | 54.95 | nM | 7.26 |
| CHEMBL5076846 | — | Ki | = | 89.13 | nM | 7.05 |
| CHEMBL5079536 | — | Ki | = | 97.72 | nM | 7.01 |
| CHEMBL5073337 | — | Ki | = | 102.33 | nM | 6.99 |
| CHEMBL5080719 | — | Ki | = | 117.49 | nM | 6.93 |
| CHEMBL5083505 | — | Ki | = | 151.36 | nM | 6.82 |
| CHEMBL5085390 | — | Ki | = | 154.88 | nM | 6.81 |