Assay Detail
Binding
CHEMBL5046640
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-methylspiperone from human D2 receptor transfected in CHO-K1 cells measured after 60 mins by scintillation counting method
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Multifunctional Arylsulfone and Arylsulfonamide-Based Ligands with Prominent Mood-Modulating Activity and Benign Safety Profile, Targeting Neuropsychiatric Symptoms of Dementia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 7.19 | 8.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.73 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 8.63 |
| CHEMBL5084167 | — | — | 1 | 8.28 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 7.77 |
| CHEMBL5092755 | — | — | 1 | 7.70 |
| CHEMBL5080719 | — | — | 1 | 7.52 |
| CHEMBL5088232 | — | — | 1 | 7.33 |
| CHEMBL5077755 | — | — | 1 | 7.30 |
| CHEMBL5079536 | — | — | 1 | 7.27 |
| CHEMBL5076846 | — | — | 1 | 7.27 |
| CHEMBL5087742 | — | — | 1 | 7.27 |
| CHEMBL5090557 | — | — | 1 | 7.26 |
| CHEMBL5080305 | — | — | 1 | 7.03 |
| CHEMBL5089348 | — | — | 1 | 7.02 |
| CHEMBL5073337 | — | — | 1 | 6.95 |
| CHEMBL5093017 | — | — | 1 | 6.89 |
| CHEMBL5080955 | — | — | 1 | 6.87 |
| CHEMBL5076882 | — | — | 1 | 6.81 |
| CHEMBL5085390 | — | — | 1 | 6.81 |
| CHEMBL5082182 | — | — | 1 | 6.79 |
| CHEMBL5077178 | — | — | 1 | 6.59 |
| CHEMBL5082267 | — | — | 1 | 6.52 |
| CHEMBL716 | QUETIAPINE | 4.0 | 1 | 6.51 |
| CHEMBL5093250 | — | — | 1 | 6.37 |
| CHEMBL5083505 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 1.862 | nM | 8.73 |
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 2.344 | nM | 8.63 |
| CHEMBL5084167 | — | Ki | = | 5.248 | nM | 8.28 |
| CHEMBL715 | OLANZAPINE | Ki | = | 16.98 | nM | 7.77 |
| CHEMBL5092755 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL5080719 | — | Ki | = | 30.2 | nM | 7.52 |
| CHEMBL5088232 | — | Ki | = | 46.77 | nM | 7.33 |
| CHEMBL5077755 | — | Ki | = | 50.12 | nM | 7.30 |
| CHEMBL5079536 | — | Ki | = | 53.7 | nM | 7.27 |
| CHEMBL5076846 | — | Ki | = | 53.7 | nM | 7.27 |
| CHEMBL5087742 | — | Ki | = | 53.7 | nM | 7.27 |
| CHEMBL5090557 | — | Ki | = | 54.95 | nM | 7.26 |
| CHEMBL5080305 | — | Ki | = | 93.33 | nM | 7.03 |
| CHEMBL5089348 | — | Ki | = | 95.5 | nM | 7.02 |
| CHEMBL5073337 | — | Ki | = | 112.2 | nM | 6.95 |
| CHEMBL5093017 | — | Ki | = | 128.82 | nM | 6.89 |
| CHEMBL5080955 | — | Ki | = | 134.9 | nM | 6.87 |
| CHEMBL5076882 | — | Ki | = | 154.88 | nM | 6.81 |
| CHEMBL5085390 | — | Ki | = | 154.88 | nM | 6.81 |
| CHEMBL5082182 | — | Ki | = | 162.18 | nM | 6.79 |
| CHEMBL5077178 | — | Ki | = | 257.04 | nM | 6.59 |
| CHEMBL5082267 | — | Ki | = | 302.0 | nM | 6.52 |
| CHEMBL716 | QUETIAPINE | Ki | = | 309.03 | nM | 6.51 |
| CHEMBL5093250 | — | Ki | = | 426.58 | nM | 6.37 |
| CHEMBL5083505 | — | Ki | = | 645.65 | nM | 6.19 |