Assay Detail
Functional
CHEMBL5046791
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Antiproliferative activity against human HGC-27 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HGC-27 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and bioactivity evaluation of novel evodiamine derivatives with excellent potency against gastric cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.61 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5084381 | — | — | 1 | 6.58 |
| CHEMBL5089958 | — | — | 1 | 6.41 |
| CHEMBL5088783 | — | — | 1 | 6.31 |
| CHEMBL5079227 | — | — | 1 | 6.25 |
| CHEMBL5075370 | — | — | 1 | 6.04 |
| CHEMBL5072392 | — | — | 1 | 5.75 |
| CHEMBL5085481 | — | — | 1 | 5.74 |
| CHEMBL5088009 | — | — | 1 | 5.64 |
| CHEMBL5089863 | — | — | 1 | 5.64 |
| CHEMBL5089162 | — | — | 1 | 5.60 |
| CHEMBL5073538 | — | — | 1 | 5.60 |
| CHEMBL5069960 | — | — | 1 | 5.47 |
| CHEMBL5094503 | — | — | 1 | 5.34 |
| CHEMBL5082035 | — | — | 1 | 5.33 |
| CHEMBL5085517 | — | — | 1 | 5.31 |
| CHEMBL5090109 | — | — | 1 | 5.31 |
| CHEMBL5079574 | — | — | 1 | 5.20 |
| CHEMBL5089779 | — | — | 1 | 5.13 |
| CHEMBL5079362 | — | — | 1 | 5.09 |
| CHEMBL5083769 | — | — | 1 | 5.03 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 4.97 |
| CHEMBL5088943 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5084381 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5089958 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5088783 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL5079227 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL5075370 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL5072392 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL5085481 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL5088009 | — | IC50 | = | 2290.0 | nM | 5.64 |
| CHEMBL5089863 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL5089162 | — | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL5073538 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL5069960 | — | IC50 | = | 3410.0 | nM | 5.47 |
| CHEMBL5094503 | — | IC50 | = | 4560.0 | nM | 5.34 |
| CHEMBL5082035 | — | IC50 | = | 4730.0 | nM | 5.33 |
| CHEMBL5085517 | — | IC50 | = | 4920.0 | nM | 5.31 |
| CHEMBL5090109 | — | IC50 | = | 4860.0 | nM | 5.31 |
| CHEMBL5079574 | — | IC50 | = | 6360.0 | nM | 5.20 |
| CHEMBL5089779 | — | IC50 | = | 7480.0 | nM | 5.13 |
| CHEMBL5079362 | — | IC50 | = | 8060.0 | nM | 5.09 |
| CHEMBL5083769 | — | IC50 | = | 9240.0 | nM | 5.03 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 10820.0 | nM | 4.97 |
| CHEMBL5088943 | — | IC50 | > | 18000.0 | nM | - |