Assay Detail
Functional
CHEMBL5046947
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth measured after 48 hrs by sulforhodamine B assay
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Branched alkyl of phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates as unique cytochrome P450 1A1-activated antimitotic prodrugs: Biological evaluation and mechanism of bioactivation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 49 | 4.74 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4078072 | — | — | 1 | 5.37 |
| CHEMBL5079907 | — | — | 1 | 5.35 |
| CHEMBL5091347 | — | — | 1 | 5.28 |
| CHEMBL5090081 | — | — | 1 | 5.15 |
| CHEMBL5080353 | — | — | 1 | 5.12 |
| CHEMBL5080130 | — | — | 1 | 5.08 |
| CHEMBL5081361 | — | — | 1 | 4.94 |
| CHEMBL5085269 | — | — | 1 | 4.93 |
| CHEMBL5082015 | — | — | 1 | 4.92 |
| CHEMBL5094697 | — | — | 1 | 4.90 |
| CHEMBL5069568 | — | — | 1 | 4.89 |
| CHEMBL5085960 | — | — | 1 | 4.89 |
| CHEMBL5093976 | — | — | 1 | 4.85 |
| CHEMBL5084275 | — | — | 1 | 4.80 |
| CHEMBL5073153 | — | — | 1 | 4.80 |
| CHEMBL5093679 | — | — | 1 | 4.80 |
| CHEMBL5072513 | — | — | 1 | 4.76 |
| CHEMBL5088085 | — | — | 1 | 4.75 |
| CHEMBL5088244 | — | — | 1 | 4.75 |
| CHEMBL5093881 | — | — | 1 | 4.70 |
| CHEMBL5086667 | — | — | 1 | 4.70 |
| CHEMBL5077196 | — | — | 1 | 4.64 |
| CHEMBL5083284 | — | — | 1 | 4.58 |
| CHEMBL5082341 | — | — | 1 | 4.54 |
| CHEMBL5092640 | — | — | 1 | 4.52 |
| CHEMBL5092301 | — | — | 1 | 4.50 |
| CHEMBL5079491 | — | — | 1 | 4.50 |
| CHEMBL5089888 | — | — | 1 | 4.48 |
| CHEMBL5094487 | — | — | 1 | 4.46 |
| CHEMBL5085272 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4078072 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL5079907 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL5091347 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL5090081 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL5080353 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL5080130 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL5081361 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL5085269 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL5082015 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL5094697 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL5069568 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL5085960 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL5093976 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL5093679 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL5084275 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL5073153 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL5072513 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL5088085 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL5088244 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL5093881 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5086667 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5077196 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL5083284 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL5082341 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL5092640 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL5079491 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL5092301 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL5089888 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL5094487 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL5085272 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL5075783 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL5086514 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL5090124 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL5078048 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL5088479 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL5078523 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5078435 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5077482 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5078224 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5080048 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5082337 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5089842 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5078398 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5088497 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5073496 | — | IC50 | > | 29000.0 | nM | - |
| CHEMBL5077719 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5084238 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5080139 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5083338 | — | IC50 | > | 100000.0 | nM | - |