Assay Detail
Functional
CHEMBL5046949
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human M21 cells assessed as inhibition of cell growth measured after 48 hrs by sulforhodamine B assay
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | M21 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Branched alkyl of phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates as unique cytochrome P450 1A1-activated antimitotic prodrugs: Biological evaluation and mechanism of bioactivation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 49 | 4.62 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4078072 | — | — | 1 | 5.43 |
| CHEMBL5091347 | — | — | 1 | 5.17 |
| CHEMBL5079907 | — | — | 1 | 5.12 |
| CHEMBL5080130 | — | — | 1 | 5.09 |
| CHEMBL5081361 | — | — | 1 | 4.80 |
| CHEMBL5082015 | — | — | 1 | 4.79 |
| CHEMBL5080353 | — | — | 1 | 4.72 |
| CHEMBL5069568 | — | — | 1 | 4.68 |
| CHEMBL5088244 | — | — | 1 | 4.66 |
| CHEMBL5094697 | — | — | 1 | 4.64 |
| CHEMBL5090081 | — | — | 1 | 4.62 |
| CHEMBL5086667 | — | — | 1 | 4.60 |
| CHEMBL5085269 | — | — | 1 | 4.57 |
| CHEMBL5084275 | — | — | 1 | 4.50 |
| CHEMBL5085272 | — | — | 1 | 4.44 |
| CHEMBL5072513 | — | — | 1 | 4.38 |
| CHEMBL5085960 | — | — | 1 | 4.29 |
| CHEMBL5089888 | — | — | 1 | 4.21 |
| CHEMBL5093679 | — | — | 1 | 4.16 |
| CHEMBL5093976 | — | — | 1 | 4.05 |
| CHEMBL5088479 | — | — | 1 | 4.02 |
| CHEMBL5094487 | — | — | 1 | - |
| CHEMBL5092640 | — | — | 1 | - |
| CHEMBL5082341 | — | — | 1 | - |
| CHEMBL5078224 | — | — | 1 | - |
| CHEMBL5080048 | — | — | 1 | - |
| CHEMBL5078398 | — | — | 1 | - |
| CHEMBL5078048 | — | — | 1 | - |
| CHEMBL5088497 | — | — | 1 | - |
| CHEMBL5073496 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4078072 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL5091347 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL5079907 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL5080130 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL5081361 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL5082015 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL5080353 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL5069568 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL5088244 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL5094697 | — | IC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL5090081 | — | IC50 | = | 24100.0 | nM | 4.62 |
| CHEMBL5086667 | — | IC50 | = | 25200.0 | nM | 4.60 |
| CHEMBL5085269 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL5084275 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL5085272 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL5072513 | — | IC50 | = | 41500.0 | nM | 4.38 |
| CHEMBL5085960 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL5089888 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL5093679 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL5093976 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL5088479 | — | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL5086514 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5090124 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5078523 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5077196 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5073153 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5092301 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5093881 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5075783 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5077482 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5082337 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5089842 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5084238 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5080139 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5083338 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5083284 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5078435 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5088085 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5079491 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5077719 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL5073496 | — | IC50 | > | 29000.0 | nM | - |
| CHEMBL5088497 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5078048 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5078398 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5080048 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5078224 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5082341 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5092640 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5094487 | — | IC50 | > | 100000.0 | nM | - |