Assay Detail
Functional
CHEMBL5046950
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth measured after 48 hrs by sulforhodamine B assay
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Branched alkyl of phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates as unique cytochrome P450 1A1-activated antimitotic prodrugs: Biological evaluation and mechanism of bioactivation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 49 | 5.05 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4078072 | — | — | 1 | 7.22 |
| CHEMBL5084275 | — | — | 1 | 6.89 |
| CHEMBL5077719 | — | — | 1 | 6.62 |
| CHEMBL5073496 | — | — | 1 | 6.41 |
| CHEMBL5079907 | — | — | 1 | 6.32 |
| CHEMBL5079491 | — | — | 1 | 6.16 |
| CHEMBL5078048 | — | — | 1 | 5.89 |
| CHEMBL5088479 | — | — | 1 | 5.62 |
| CHEMBL5085269 | — | — | 1 | 5.47 |
| CHEMBL5080048 | — | — | 1 | 5.38 |
| CHEMBL5080353 | — | — | 1 | 5.27 |
| CHEMBL5091347 | — | — | 1 | 5.21 |
| CHEMBL5082341 | — | — | 1 | 5.16 |
| CHEMBL5080130 | — | — | 1 | 5.05 |
| CHEMBL5081361 | — | — | 1 | 5.00 |
| CHEMBL5086667 | — | — | 1 | 4.96 |
| CHEMBL5093976 | — | — | 1 | 4.89 |
| CHEMBL5090081 | — | — | 1 | 4.87 |
| CHEMBL5094697 | — | — | 1 | 4.81 |
| CHEMBL5082015 | — | — | 1 | 4.73 |
| CHEMBL5069568 | — | — | 1 | 4.68 |
| CHEMBL5072513 | — | — | 1 | 4.58 |
| CHEMBL5089888 | — | — | 1 | 4.52 |
| CHEMBL5085960 | — | — | 1 | 4.51 |
| CHEMBL5094487 | — | — | 1 | 4.48 |
| CHEMBL5085272 | — | — | 1 | 4.48 |
| CHEMBL5093679 | — | — | 1 | 4.42 |
| CHEMBL5088244 | — | — | 1 | 4.39 |
| CHEMBL5086514 | — | — | 1 | 4.37 |
| CHEMBL5093881 | — | — | 1 | 4.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4078072 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5084275 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5077719 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5073496 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5079907 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL5079491 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5078048 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5088479 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5085269 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL5080048 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL5080353 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL5091347 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL5082341 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL5080130 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL5081361 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5086667 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5093976 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL5090081 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL5094697 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL5082015 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL5069568 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL5072513 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL5089888 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL5085960 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL5094487 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL5085272 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL5093679 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL5088244 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL5086514 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL5093881 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL5083284 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL5088085 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL5073153 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL5077196 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL5078224 | — | IC50 | = | 84000.0 | nM | 4.08 |
| CHEMBL5092640 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL5078523 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5092301 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5078435 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5075783 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5077482 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5082337 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5078398 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5089842 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5088497 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5084238 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5080139 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5090124 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5083338 | — | IC50 | > | 100000.0 | nM | - |