Assay Detail
Functional
CHEMBL5046954
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Antiproliferative activity against CYP1A1 expressing human MDA-MB-468 cells assessed as inhibition of cell growth measured after 48 hrs by sulforhodamine B assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-468 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Branched alkyl of phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates as unique cytochrome P450 1A1-activated antimitotic prodrugs: Biological evaluation and mechanism of bioactivation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.36 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4078072 | — | — | 1 | 7.22 |
| CHEMBL5084275 | — | — | 1 | 6.42 |
| CHEMBL5077719 | — | — | 1 | 6.18 |
| CHEMBL5073496 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4078072 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5084275 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL5077719 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL5073496 | — | IC50 | = | 2400.0 | nM | 5.62 |