Assay Detail
Binding
CHEMBL5047394
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BuChE in mouse serum using butyrylthiocholine iodide as substrate incubated for 20 mins by Ellman's method
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Serum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 51 | 5.76 | 6.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5076629 | — | — | 1 | 6.74 |
| CHEMBL5071558 | — | — | 1 | 6.49 |
| CHEMBL5087351 | — | — | 1 | 6.47 |
| CHEMBL5087878 | — | — | 1 | 6.46 |
| CHEMBL5080857 | — | — | 1 | 6.30 |
| CHEMBL5089999 | — | — | 1 | 6.26 |
| CHEMBL5076406 | — | — | 1 | 6.20 |
| CHEMBL5082360 | — | — | 1 | 6.16 |
| CHEMBL5089691 | — | — | 1 | 6.13 |
| CHEMBL5088143 | — | — | 1 | 6.05 |
| CHEMBL5086121 | — | — | 1 | 6.04 |
| CHEMBL5076277 | — | — | 1 | 6.01 |
| CHEMBL5087923 | — | — | 1 | 6.01 |
| CHEMBL5070726 | — | — | 1 | 6.00 |
| CHEMBL5094829 | — | — | 1 | 5.95 |
| CHEMBL5088281 | — | — | 1 | 5.94 |
| CHEMBL5088060 | — | — | 1 | 5.92 |
| CHEMBL5086036 | — | — | 1 | 5.92 |
| CHEMBL5077564 | — | — | 1 | 5.88 |
| CHEMBL5092455 | — | — | 1 | 5.87 |
| CHEMBL5080825 | — | — | 1 | 5.85 |
| CHEMBL5087922 | — | — | 1 | 5.83 |
| CHEMBL5082836 | — | — | 1 | 5.83 |
| CHEMBL5069928 | — | — | 1 | 5.78 |
| CHEMBL5087461 | — | — | 1 | 5.78 |
| CHEMBL5088366 | — | — | 1 | 5.75 |
| CHEMBL5087445 | — | — | 1 | 5.73 |
| CHEMBL5087427 | — | — | 1 | 5.72 |
| CHEMBL5085893 | — | — | 1 | 5.70 |
| CHEMBL5080984 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5076629 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL5071558 | — | IC50 | = | 325.0 | nM | 6.49 |
| CHEMBL5087351 | — | IC50 | = | 336.0 | nM | 6.47 |
| CHEMBL5087878 | — | IC50 | = | 351.0 | nM | 6.46 |
| CHEMBL5080857 | — | IC50 | = | 498.0 | nM | 6.30 |
| CHEMBL5089999 | — | IC50 | = | 551.0 | nM | 6.26 |
| CHEMBL5076406 | — | IC50 | = | 638.0 | nM | 6.20 |
| CHEMBL5082360 | — | IC50 | = | 687.0 | nM | 6.16 |
| CHEMBL5089691 | — | IC50 | = | 743.0 | nM | 6.13 |
| CHEMBL5088143 | — | IC50 | = | 883.0 | nM | 6.05 |
| CHEMBL5086121 | — | IC50 | = | 902.0 | nM | 6.04 |
| CHEMBL5076277 | — | IC50 | = | 986.0 | nM | 6.01 |
| CHEMBL5087923 | — | IC50 | = | 979.0 | nM | 6.01 |
| CHEMBL5070726 | — | IC50 | = | 1004.0 | nM | 6.00 |
| CHEMBL5094829 | — | IC50 | = | 1128.0 | nM | 5.95 |
| CHEMBL5088281 | — | IC50 | = | 1152.0 | nM | 5.94 |
| CHEMBL5088060 | — | IC50 | = | 1203.0 | nM | 5.92 |
| CHEMBL5086036 | — | IC50 | = | 1197.0 | nM | 5.92 |
| CHEMBL5077564 | — | IC50 | = | 1324.0 | nM | 5.88 |
| CHEMBL5092455 | — | IC50 | = | 1345.0 | nM | 5.87 |
| CHEMBL5080825 | — | IC50 | = | 1401.0 | nM | 5.85 |
| CHEMBL5087922 | — | IC50 | = | 1472.0 | nM | 5.83 |
| CHEMBL5082836 | — | IC50 | = | 1489.0 | nM | 5.83 |
| CHEMBL5069928 | — | IC50 | = | 1672.0 | nM | 5.78 |
| CHEMBL5087461 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL5088366 | — | IC50 | = | 1763.0 | nM | 5.75 |
| CHEMBL5087445 | — | IC50 | = | 1864.0 | nM | 5.73 |
| CHEMBL5087427 | — | IC50 | = | 1905.0 | nM | 5.72 |
| CHEMBL5085893 | — | IC50 | = | 2008.0 | nM | 5.70 |
| CHEMBL5080984 | — | IC50 | = | 1997.0 | nM | 5.70 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 1992.0 | nM | 5.70 |
| CHEMBL5082250 | — | IC50 | = | 2176.0 | nM | 5.66 |
| CHEMBL5079986 | — | IC50 | = | 2383.0 | nM | 5.62 |
| CHEMBL5093872 | — | IC50 | = | 2515.0 | nM | 5.60 |
| CHEMBL5094743 | — | IC50 | = | 2639.0 | nM | 5.58 |
| CHEMBL5089630 | — | IC50 | = | 2676.0 | nM | 5.57 |
| CHEMBL5090651 | — | IC50 | = | 2723.0 | nM | 5.57 |
| CHEMBL5080308 | — | IC50 | = | 2731.0 | nM | 5.56 |
| CHEMBL5078629 | — | IC50 | = | 2842.0 | nM | 5.55 |
| CHEMBL5072039 | — | IC50 | = | 2832.0 | nM | 5.55 |
| CHEMBL5071820 | — | IC50 | = | 2999.0 | nM | 5.52 |
| CHEMBL5075438 | — | IC50 | = | 3568.0 | nM | 5.45 |
| CHEMBL5085109 | — | IC50 | = | 3845.0 | nM | 5.42 |
| CHEMBL5088919 | — | IC50 | = | 4588.0 | nM | 5.34 |
| CHEMBL5091978 | — | IC50 | = | 4948.0 | nM | 5.31 |
| CHEMBL5094506 | — | IC50 | = | 5805.0 | nM | 5.24 |
| CHEMBL5075295 | — | IC50 | = | 5845.0 | nM | 5.23 |
| CHEMBL5072034 | — | IC50 | = | 6746.0 | nM | 5.17 |
| CHEMBL5092918 | — | IC50 | = | 11339.0 | nM | 4.95 |
| CHEMBL5078724 | — | IC50 | = | 13418.0 | nM | 4.87 |