Assay Detail
Functional
CHEMBL5047503
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HepG2 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.88 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10557 | — | — | 1 | 7.00 |
| CHEMBL3337992 | — | — | 1 | 5.96 |
| CHEMBL254186 | — | — | 1 | 5.76 |
| CHEMBL219553 | GIGANTOL | — | 1 | 5.72 |
| CHEMBL5093670 | — | — | 1 | 5.59 |
| CHEMBL5085855 | — | — | 1 | 5.58 |
| CHEMBL374047 | MOSCATILIN | — | 1 | 5.52 |
| CHEMBL5078918 | — | — | 1 | - |
| CHEMBL426871 | — | — | 1 | - |
| CHEMBL109266 | RHAPONTIN | — | 1 | - |
| CHEMBL5089298 | — | — | 1 | - |
| CHEMBL5093275 | — | — | 1 | - |
| CHEMBL5084109 | — | — | 1 | - |
| CHEMBL5076060 | — | — | 1 | - |
| CHEMBL475652 | HIRCINOL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10557 | — | IC50 | = | 99.26 | nM | 7.00 |
| CHEMBL3337992 | — | IC50 | = | 1094.0 | nM | 5.96 |
| CHEMBL254186 | — | IC50 | = | 1741.0 | nM | 5.76 |
| CHEMBL219553 | GIGANTOL | IC50 | = | 1883.0 | nM | 5.72 |
| CHEMBL5093670 | — | IC50 | = | 2575.0 | nM | 5.59 |
| CHEMBL5085855 | — | IC50 | = | 2660.0 | nM | 5.58 |
| CHEMBL374047 | MOSCATILIN | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL5078918 | — | IC50 | > | 6420.0 | nM | - |
| CHEMBL426871 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL109266 | RHAPONTIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL5089298 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5093275 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5084109 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5076060 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL475652 | HIRCINOL | IC50 | > | 100000.0 | nM | - |