Assay Detail
Binding
CHEMBL5047545
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Inhibition of pyruvate carboxylase in human HCCLM3 cell lysate measured upto 24 hrs by PC assay kit
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HCCLM3 |
| Subcellular | Lysate |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.06 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10557 | — | — | 1 | 8.29 |
| CHEMBL5085855 | — | — | 1 | 7.19 |
| CHEMBL1794791 | OXALOACETATE | 2.0 | 1 | 7.05 |
| CHEMBL219553 | GIGANTOL | — | 1 | 6.90 |
| CHEMBL374047 | MOSCATILIN | — | 1 | 6.72 |
| CHEMBL254186 | — | — | 1 | 6.69 |
| CHEMBL5093670 | — | — | 1 | 6.58 |
| CHEMBL3337992 | — | — | 1 | - |
| CHEMBL426871 | — | — | 1 | - |
| CHEMBL109266 | RHAPONTIN | — | 1 | - |
| CHEMBL5089298 | — | — | 1 | - |
| CHEMBL5093275 | — | — | 1 | - |
| CHEMBL5084109 | — | — | 1 | - |
| CHEMBL5076060 | — | — | 1 | - |
| CHEMBL5078918 | — | — | 1 | - |
| CHEMBL475652 | HIRCINOL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10557 | — | IC50 | = | 5.184 | nM | 8.29 |
| CHEMBL5085855 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL1794791 | OXALOACETATE | IC50 | = | 88.8 | nM | 7.05 |
| CHEMBL219553 | GIGANTOL | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL374047 | MOSCATILIN | IC50 | = | 191.0 | nM | 6.72 |
| CHEMBL254186 | — | IC50 | = | 204.0 | nM | 6.69 |
| CHEMBL5093670 | — | IC50 | = | 264.0 | nM | 6.58 |
| CHEMBL3337992 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL426871 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL109266 | RHAPONTIN | IC50 | > | 50000.0 | nM | - |
| CHEMBL5089298 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5093275 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5084109 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5076060 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5078918 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL475652 | HIRCINOL | IC50 | > | 50000.0 | nM | - |