Assay Detail
Binding
CHEMBL5048619
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human full-length HDAC2 preincubated for 20 mins with DTT followed by enzyme addition and measured after 10 mins by Glo-luminescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of a Novel, Small-Molecule Brain-Penetrant Histone Deacetylase Inhibitor That Enhances Spatial Memory Formation in Mice.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.77 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5086240 | — | — | 1 | 5.00 |
| CHEMBL5087342 | — | — | 1 | 4.96 |
| CHEMBL5081652 | — | — | 1 | 4.77 |
| CHEMBL5085306 | — | — | 1 | 4.75 |
| CHEMBL5084611 | — | — | 1 | 4.60 |
| CHEMBL5074871 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5086240 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5087342 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5081652 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL5085306 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL5084611 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL5074871 | — | IC50 | = | 28000.0 | nM | 4.55 |