Assay Detail
Binding
CHEMBL5048671
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Nano-Luc fused human full length CDK5/P35 transfected in HEK293 cells incubated for 1 hr by NanoBRET assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 5/CDK5 activator 1 (CHEMBL1907600) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Discovery and Optimization of Highly Selective Inhibitors of CDK5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.80 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5080866 | — | — | 1 | 9.70 |
| CHEMBL5080566 | — | — | 1 | 9.00 |
| CHEMBL5088315 | — | — | 1 | 8.92 |
| CHEMBL5078192 | — | — | 1 | 8.92 |
| CHEMBL5079342 | — | — | 1 | 8.43 |
| CHEMBL2103840 | DINACICLIB | 3.0 | 1 | 7.80 |
| CHEMBL5083778 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5080866 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5080566 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5088315 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5078192 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5079342 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL2103840 | DINACICLIB | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5083778 | — | IC50 | - | — | - |