Assay Detail
Functional
CHEMBL5048672
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Antiproliferative activity against human HEK293T cells assessed as cell growth inhibition incubated for 48 hrs
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Optimization of Highly Selective Inhibitors of CDK5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.83 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2103840 | DINACICLIB | 3.0 | 1 | 7.64 |
| CHEMBL5088315 | — | — | 1 | 5.29 |
| CHEMBL5080866 | — | — | 1 | 5.19 |
| CHEMBL5079342 | — | — | 1 | 5.19 |
| CHEMBL5078192 | — | — | 1 | - |
| CHEMBL5080566 | — | — | 1 | - |
| CHEMBL5083778 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2103840 | DINACICLIB | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL5088315 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL5080866 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL5079342 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL5078192 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5080566 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5083778 | — | IC50 | > | 10000.0 | nM | - |