Assay Detail
Binding
CHEMBL5048804
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of kappa opioid receptor (unknown origin)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.41 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5070958 | — | — | 1 | 5.96 |
| CHEMBL3091687 | — | — | 1 | 5.80 |
| CHEMBL5076569 | — | — | 1 | 5.40 |
| CHEMBL5085511 | — | — | 1 | 5.37 |
| CHEMBL5081505 | — | — | 1 | 5.32 |
| CHEMBL5077132 | — | — | 1 | 5.05 |
| CHEMBL5083458 | — | — | 1 | 5.00 |
| CHEMBL5093818 | — | — | 1 | - |
| CHEMBL5082142 | — | — | 1 | - |
| CHEMBL518924 | MAVORIXAFOR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5070958 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3091687 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5076569 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5085511 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL5081505 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL5077132 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL5083458 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL5093818 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5082142 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL518924 | MAVORIXAFOR | IC50 | > | 30000.0 | nM | - |