Assay Detail
Binding
CHEMBL5048807
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of alpha7 nicotinic acetylcholine receptor (unknown origin)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL2492) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.17 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5070958 | — | — | 1 | 5.77 |
| CHEMBL5082142 | — | — | 1 | 4.96 |
| CHEMBL5081505 | — | — | 1 | 4.77 |
| CHEMBL3091687 | — | — | 1 | - |
| CHEMBL5076569 | — | — | 1 | - |
| CHEMBL5093818 | — | — | 1 | - |
| CHEMBL5085511 | — | — | 1 | - |
| CHEMBL5077132 | — | — | 1 | - |
| CHEMBL5083458 | — | — | 1 | - |
| CHEMBL518924 | MAVORIXAFOR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5070958 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5082142 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5081505 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3091687 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5076569 | — | IC50 | - | — | - | |
| CHEMBL5093818 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5085511 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5077132 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5083458 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL518924 | MAVORIXAFOR | IC50 | > | 30000.0 | nM | - |