Assay Detail
Toxicity
CHEMBL5048808
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG by [3H]]Astemizole binding assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and Evaluation of Novel Tetrahydronaphthyridine CXCR4 Antagonists with Improved Drug-like Profiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.07 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL518924 | MAVORIXAFOR | 4.0 | 1 | 5.28 |
| CHEMBL5076569 | — | — | 1 | 5.27 |
| CHEMBL5070958 | — | — | 1 | 5.24 |
| CHEMBL3091687 | — | — | 1 | 5.05 |
| CHEMBL5081505 | — | — | 1 | 5.03 |
| CHEMBL5083458 | — | — | 1 | 4.96 |
| CHEMBL5082142 | — | — | 1 | 4.96 |
| CHEMBL5093818 | — | — | 1 | 4.77 |
| CHEMBL5085511 | — | — | 1 | - |
| CHEMBL5077132 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL518924 | MAVORIXAFOR | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL5076569 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL5070958 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL3091687 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL5081505 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL5083458 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5082142 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL5093818 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL5085511 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5077132 | — | IC50 | > | 50000.0 | nM | - |