Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL5049002

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Escherichia coli IMP-7 using fluorocillin as substrate incubated for 30 mins by fluorescence based assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Escherichia coli
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

<i>N</i>-Aryl Mercaptopropionamides as Broad-Spectrum Inhibitors of Metallo-β-Lactamases.
Kaya C, Konstantinović J, Kany AM, Andreas A, Kramer JS, Brunst S, Weizel L, Rotter MJ, Frank D, Yahiaoui S, Müller R, Hartmann RW, Haupenthal J, Proschak E, Wichelhaus TA, Hirsch AKH.
J Med Chem (2022) 65 : 3913 -3922
PubMed 35188771 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 5.47 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5084254 1 6.00
CHEMBL5088797 1 5.96
CHEMBL5078579 1 5.89
CHEMBL5079055 1 5.85
CHEMBL5092510 1 5.68
CHEMBL5085867 1 5.68
CHEMBL5077613 1 5.58
CHEMBL5085103 1 5.48
CHEMBL5076170 1 5.48
CHEMBL5084382 1 5.47
CHEMBL5086797 1 5.44
CHEMBL5086580 1 5.39
CHEMBL4790849 1 5.34
CHEMBL5093694 1 5.30
CHEMBL5082642 1 5.29
CHEMBL5085398 1 5.26
CHEMBL5070160 1 5.26
CHEMBL5075199 1 5.24
CHEMBL5090517 1 5.19
CHEMBL5083400 1 5.15
CHEMBL5079481 1 4.90
CHEMBL5094801 1 -
CHEMBL5087521 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5084254 IC50 = 1000.0 nM 6.00
CHEMBL5088797 IC50 = 1100.0 nM 5.96
CHEMBL5078579 IC50 = 1300.0 nM 5.89
CHEMBL5079055 IC50 = 1400.0 nM 5.85
CHEMBL5092510 IC50 = 2100.0 nM 5.68
CHEMBL5085867 IC50 = 2100.0 nM 5.68
CHEMBL5077613 IC50 = 2600.0 nM 5.58
CHEMBL5085103 IC50 = 3300.0 nM 5.48
CHEMBL5076170 IC50 = 3300.0 nM 5.48
CHEMBL5084382 IC50 = 3400.0 nM 5.47
CHEMBL5086797 IC50 = 3600.0 nM 5.44
CHEMBL5086580 IC50 = 4100.0 nM 5.39
CHEMBL4790849 IC50 = 4600.0 nM 5.34
CHEMBL5093694 IC50 = 5000.0 nM 5.30
CHEMBL5082642 IC50 = 5100.0 nM 5.29
CHEMBL5085398 IC50 = 5500.0 nM 5.26
CHEMBL5070160 IC50 = 5500.0 nM 5.26
CHEMBL5075199 IC50 = 5800.0 nM 5.24
CHEMBL5090517 IC50 = 6400.0 nM 5.19
CHEMBL5083400 IC50 = 7100.0 nM 5.15
CHEMBL5079481 IC50 = 12600.0 nM 4.90
CHEMBL5094801 IC50 > 10000.0 nM -
CHEMBL5087521 IC50 > 10000.0 nM -