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Assay Detail

CHEMBL5049012

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human MMP-2
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

72 kDa type IV collagenase (CHEMBL333)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

<i>N</i>-Aryl Mercaptopropionamides as Broad-Spectrum Inhibitors of Metallo-β-Lactamases.
Kaya C, Konstantinović J, Kany AM, Andreas A, Kramer JS, Brunst S, Weizel L, Rotter MJ, Frank D, Yahiaoui S, Müller R, Hartmann RW, Haupenthal J, Proschak E, Wichelhaus TA, Hirsch AKH.
J Med Chem (2022) 65 : 3913 -3922
PubMed 35188771 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 4.19 4.19

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5079481 1 4.19

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5079481 IC50 = 64000.0 nM 4.19